Diagnosing secondary HLH/MAS: Tools, trends, and challenges

Episode 2. Francesca Minoia, a key contributor to the 2016 MAS classification criteria, chats with Michael Jordan to reflect on the study’s impact, the significance of lab trends, and the evolving role of biomarkers in diagnosis. They discuss challenges in early recognition, particularly in patients receiving biologics or presenting with MAS as an initial symptom, and how diagnostic tools are reshaping clinical practice.